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Literature summary for 3.4.24.82 extracted from
- A highly selective hydantoin inhibitor of aggrecanase-1 and aggrecanase-2 with a low projected human dose (2017), J. Med. Chem., 60, 5933-5939 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-[[(4R)-4-cyclopropyl-2,5-dioxoimidazolidin-4-yl]methyl]-5-(trifluoromethyl)-1-benzofuran-2-carboxamide | - |
Homo sapiens |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | dependent on | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O75173 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cartilage | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | - |
Homo sapiens | ? | - |
? | |
| VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS-4 | - |
Homo sapiens |
| aggrecanase-1 | isoform | Homo sapiens |
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